Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS

The Casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the common deleted region for del(5q) myelodysplastic syndrome (MDS). We generated a murine model with conditional inactivation of Csnk1a1 and found that Csnk1a1 haploinsufficiency induces hematopoietic stem cell exp...

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Bibliographic Details
Main Authors: Schneider, Rebekka K., Ademà, Vera, Heckl, Dirk, Järås, Marcus, Mallo, Mar, Lord, Allegra M., Chu, Lisa P., McConkey, Marie E., Kramann, Rafael, Mullally, Ann, Bejar, Rafael, Solé, Francesc, Ebert, Benjamin L.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199102/
https://ncbi.nlm.nih.gov/pubmed/25242043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.08.001
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