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DNA end joining becomes less efficient and more error-prone during cellular senescence

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic instability has been shown to increase during aging, suggesting an aberrant function of DNA double-strand break (DSB) repair. Surprisingly, DSB repair has not been examined with respect to cellular senescence. T...

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Detaylı Bibliyografya
Asıl Yazarlar: Seluanov, Andrei, Mittelman, David, Pereira-Smith, Olivia M., Wilson, John H., Gorbunova, Vera
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC419656/
https://ncbi.nlm.nih.gov/pubmed/15123826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400726101
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