DNA end joining becomes less efficient and more error-prone during cellular senescence

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic instability has been shown to increase during aging, suggesting an aberrant function of DNA double-strand break (DSB) repair. Surprisingly, DSB repair has not been examined with respect to cellular senescence. T...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Seluanov, Andrei, Mittelman, David, Pereira-Smith, Olivia M., Wilson, John H., Gorbunova, Vera
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400726101
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