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Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
Carriers of BRCA2 germline mutations are at high risk to develop early-onset breast cancer. The underlying mechanisms of how BRCA2 inactivation predisposes to malignant transformation have not been established. Here, we provide direct functional evidence that human BRCA2 promotes homologous recombin...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC37489/ https://ncbi.nlm.nih.gov/pubmed/11447276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151253498 |
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