Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Carriers of BRCA2 germline mutations are at high risk to develop early-onset breast cancer. The underlying mechanisms of how BRCA2 inactivation predisposes to malignant transformation have not been established. Here, we provide direct functional evidence that human BRCA2 promotes homologous recombin...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Xia, Fen, Taghian, Danielle G., DeFrank, Jeffrey S., Zeng, Zhao-Chong, Willers, Henning, Iliakis, George, Powell, Simon N.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2001
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC37489/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11447276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.151253498
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