Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

Carriers of BRCA2 germline mutations are at high risk to develop early-onset breast cancer. The underlying mechanisms of how BRCA2 inactivation predisposes to malignant transformation have not been established. Here, we provide direct functional evidence that human BRCA2 promotes homologous recombin...

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Bibliografske podrobnosti
Main Authors: Xia, Fen, Taghian, Danielle G., DeFrank, Jeffrey S., Zeng, Zhao-Chong, Willers, Henning, Iliakis, George, Powell, Simon N.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC37489/
https://ncbi.nlm.nih.gov/pubmed/11447276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151253498
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