DNA end joining becomes less efficient and more error-prone during cellular senescence

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic instability has been shown to increase during aging, suggesting an aberrant function of DNA double-strand break (DSB) repair. Surprisingly, DSB repair has not been examined with respect to cellular senescence. T...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Seluanov, Andrei, Mittelman, David, Pereira-Smith, Olivia M., Wilson, John H., Gorbunova, Vera
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2004
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15123826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400726101
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