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DNA end joining becomes less efficient and more error-prone during cellular senescence

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic instability has been shown to increase during aging, suggesting an aberrant function of DNA double-strand break (DSB) repair. Surprisingly, DSB repair has not been examined with respect to cellular senescence. T...

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מידע ביבליוגרפי
Main Authors: Seluanov, Andrei, Mittelman, David, Pereira-Smith, Olivia M., Wilson, John H., Gorbunova, Vera
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2004
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC419656/
https://ncbi.nlm.nih.gov/pubmed/15123826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400726101
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