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DNA end joining becomes less efficient and more error-prone during cellular senescence

Accumulation of somatic mutations is thought to contribute to the aging process. Genomic instability has been shown to increase during aging, suggesting an aberrant function of DNA double-strand break (DSB) repair. Surprisingly, DSB repair has not been examined with respect to cellular senescence. T...

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Autori principali: Seluanov, Andrei, Mittelman, David, Pereira-Smith, Olivia M., Wilson, John H., Gorbunova, Vera
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC419656/
https://ncbi.nlm.nih.gov/pubmed/15123826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400726101
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