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Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks
Identification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a novel framework for the systematic discovery of genetic alterations that are causal determinants of disease, by prioritizing genes upstream of functio...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4194029/ https://ncbi.nlm.nih.gov/pubmed/25303533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.021 |
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