DN-02 VULNERABILITY AND RΓESISTANCE TO Wee1 INHIBITION IN GBM

Approximately 87% of GBMs have abnormalities in the p53 pathway. In the absence of functional p53, cell cycle G1 checkpoint control is compromised, and proliferative cells become highly reliant on G2 checkpoint control, largely regulated by Wee1 kinase. Activated Wee1 inhibits CDC2 function, thereby...

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Hauptverfasser: Dhruv, Harshil, Nelson, Andrew, Whitsett, Timothy, Tran, Nhan, Berens, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218029/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou245.2
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