Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks

Identification of driver mutations in human diseases is often limited by cohort size and availability of appropriate statistical models. We propose a novel framework for the systematic discovery of genetic alterations that are causal determinants of disease, by prioritizing genes upstream of functio...

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Autores principales: Chen, James C., Alvarez, Mariano J., Talos, Flaminia, Dhruv, Harshil, Rieckhof, Gabrielle E., Iyer, Archana, Diefes, Kristin L., Aldape, Kenneth, Berens, Michael, Shen, Michael M., Califano, Andrea
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194029/
https://ncbi.nlm.nih.gov/pubmed/25303533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.021
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