Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts but their functional contribution remains unknown. Transgenic mice with ability to delete αSMA(+) myofibroblasts in pancreatic cancer were generated. Depletion starting at either non-invasive precur...

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Detaylı Bibliyografya
Asıl Yazarlar: Özdemir, Berna C., Pentcheva-Hoang, Tsvetelina, Carstens, Julienne L., Zheng, Xiaofeng, Wu, Chin-Chia, Simpson, Tyler, Laklai, Hanane, Sugimoto, Hikaru, Kahlert, Christoph, Novitskiy, Sergey V., Acosta, Ana DeJesus, Sharma, Padmanee, Heidari, Pedram, Mahmood, Umar, Chin, Lynda, Moses, Harold, Weaver, Valerie, Maitra, Anirban, Allison, James P., LeBleu, Valerie S., Kalluri, Raghu
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180632/
https://ncbi.nlm.nih.gov/pubmed/24856586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.005
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