Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts but their functional contribution remains unknown. Transgenic mice with ability to delete αSMA(+) myofibroblasts in pancreatic cancer were generated. Depletion starting at either non-invasive precur...

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Main Authors: Özdemir, Berna C., Pentcheva-Hoang, Tsvetelina, Carstens, Julienne L., Zheng, Xiaofeng, Wu, Chin-Chia, Simpson, Tyler, Laklai, Hanane, Sugimoto, Hikaru, Kahlert, Christoph, Novitskiy, Sergey V., Acosta, Ana DeJesus, Sharma, Padmanee, Heidari, Pedram, Mahmood, Umar, Chin, Lynda, Moses, Harold, Weaver, Valerie, Maitra, Anirban, Allison, James P., LeBleu, Valerie S., Kalluri, Raghu
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180632/
https://ncbi.nlm.nih.gov/pubmed/24856586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.005
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