Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts but their functional contribution remains unknown. Transgenic mice with ability to delete αSMA(+) myofibroblasts in pancreatic cancer were generated. Depletion starting at either non-invasive precur...

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Hauptverfasser: Özdemir, Berna C., Pentcheva-Hoang, Tsvetelina, Carstens, Julienne L., Zheng, Xiaofeng, Wu, Chin-Chia, Simpson, Tyler, Laklai, Hanane, Sugimoto, Hikaru, Kahlert, Christoph, Novitskiy, Sergey V., Acosta, Ana DeJesus, Sharma, Padmanee, Heidari, Pedram, Mahmood, Umar, Chin, Lynda, Moses, Harold, Weaver, Valerie, Maitra, Anirban, Allison, James P., LeBleu, Valerie S., Kalluri, Raghu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4180632/
https://ncbi.nlm.nih.gov/pubmed/24856586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.04.005
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