Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage

Argonaute proteins bind small RNAs and mediate cleavage of complementary target RNAs. The human Argonaute protein Ago4 is catalytically inactive, although it is highly similar to catalytic Ago2. Here, we have generated Ago2-Ago4 chimeras and analyzed their cleavage activity in vitro. We identify sev...

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Autores principales: Hauptmann, Judith, Kater, Lukas, Löffler, Patrick, Merkl, Rainer, Meister, Gunter
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4174435/
https://ncbi.nlm.nih.gov/pubmed/25114291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.045203.114
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