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Generation of catalytic human Ago4 identifies structural elements important for RNA cleavage
Argonaute proteins bind small RNAs and mediate cleavage of complementary target RNAs. The human Argonaute protein Ago4 is catalytically inactive, although it is highly similar to catalytic Ago2. Here, we have generated Ago2-Ago4 chimeras and analyzed their cleavage activity in vitro. We identify sev...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4174435/ https://ncbi.nlm.nih.gov/pubmed/25114291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.045203.114 |
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