The NHL domain of BRAT is an RNA-binding domain that directly contacts the hunchback mRNA for regulation

The Drosophila protein brain tumor (Brat) forms a complex with Pumilio (Pum) and Nanos (Nos) to repress hunchback (hb) mRNA translation at the posterior pole during early embryonic development. It is currently thought that complex formation is initiated by Pum, which directly binds the hb mRNA and s...

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Detalhes bibliográficos
Main Authors: Loedige, Inga, Stotz, Mathias, Qamar, Saadia, Kramer, Katharina, Hennig, Janosch, Schubert, Thomas, Löffler, Patrick, Längst, Gernot, Merkl, Rainer, Urlaub, Henning, Meister, Gunter
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015489/
https://ncbi.nlm.nih.gov/pubmed/24696456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.236513.113
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