Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB

[Image: see text] The structurally related exocyclic guanine adducts α-hydroxypropano-dG (α-OH-PdG), γ-hydroxypropano-dG (γ-OH-PdG), and M(1)dG are formed when DNA is exposed to the reactive aldehydes acrolein and malondialdehyde (MDA). These lesions are believed to form the basis for the observed c...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Singh, Vipender, Fedeles, Bogdan I., Li, Deyu, Delaney, James C., Kozekov, Ivan D., Kozekova, Albena, Marnett, Lawrence J., Rizzo, Carmelo J., Essigmann, John M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2014
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164229/
https://ncbi.nlm.nih.gov/pubmed/25157679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5002817
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak