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Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB
[Image: see text] The structurally related exocyclic guanine adducts α-hydroxypropano-dG (α-OH-PdG), γ-hydroxypropano-dG (γ-OH-PdG), and M(1)dG are formed when DNA is exposed to the reactive aldehydes acrolein and malondialdehyde (MDA). These lesions are believed to form the basis for the observed c...
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| Główni autorzy: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Chemical
Society
2014
|
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4164229/ https://ncbi.nlm.nih.gov/pubmed/25157679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5002817 |
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