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Exocyclic Carbons Adjacent to the N(6) of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB
[Image: see text] The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjac...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2012
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3363417/ https://ncbi.nlm.nih.gov/pubmed/22512456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3010094 |
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