Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry

DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage. AlkB, one of the Escherichia coli adaptive response proteins, uses an α-ketoglutarate/Fe(II)-dependent mechanism...

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Autors principals: Li, Deyu, Delaney, James C., Page, Charlotte M., Chen, Alvin S., Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Format: Artigo
Idioma:Inglês
Publicat: SAGE-Hindawi Access to Research 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965429/
https://ncbi.nlm.nih.gov/pubmed/21048928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2010/369434
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