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Removal of N-Alkyl Modifications from N(2)-Alkylguanine and N(4)-Alkylcytosine in DNA by the Adaptive Response Protein AlkB
[Image: see text] The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alkyl adducts, such as 1-methyladeni...
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| Main Authors: | , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
American
Chemical Society
2013
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| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3748507/ https://ncbi.nlm.nih.gov/pubmed/23773213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400096m |
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