Removal of N-Alkyl Modifications from N(2)-Alkylguanine and N(4)-Alkylcytosine in DNA by the Adaptive Response Protein AlkB

[Image: see text] The AlkB enzyme is an Fe(II)- and α-ketoglutarate-dependent dioxygenase that repairs DNA alkyl lesions by a direct reversal of damage mechanism as part of the adaptive response in E. coli. The reported substrate scope of AlkB includes simple DNA alkyl adducts, such as 1-methyladeni...

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Detalhes bibliográficos
Main Authors: Li, Deyu, Fedeles, Bogdan I., Shrivastav, Nidhi, Delaney, James C., Yang, Xuedong, Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748507/
https://ncbi.nlm.nih.gov/pubmed/23773213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400096m
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