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Alleviation of 1,N(6)-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB

1,N(6)-ethanoadenine (EA) forms through the reaction of adenine in DNA with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic used to combat various brain, head, and neck tumors. Previous studies of the toxic and mutagenic properties of the DNA adduct EA have been limited...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Frick, Lauren E., Delaney, James C., Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783386/
https://ncbi.nlm.nih.gov/pubmed/17213319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607377104
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