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Alleviation of 1,N(6)-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB
1,N(6)-ethanoadenine (EA) forms through the reaction of adenine in DNA with the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic used to combat various brain, head, and neck tumors. Previous studies of the toxic and mutagenic properties of the DNA adduct EA have been limited...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783386/ https://ncbi.nlm.nih.gov/pubmed/17213319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607377104 |
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