Exocyclic Carbons Adjacent to the N(6) of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

[Image: see text] The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjac...

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Main Authors: Li, Deyu, Delaney, James C., Page, Charlotte M., Yang, Xuedong, Chen, Alvin S., Wong, Cintyu, Drennan, Catherine L., Essigmann, John M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2012
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3363417/
https://ncbi.nlm.nih.gov/pubmed/22512456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3010094
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