Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB

[Image: see text] The structurally related exocyclic guanine adducts α-hydroxypropano-dG (α-OH-PdG), γ-hydroxypropano-dG (γ-OH-PdG), and M(1)dG are formed when DNA is exposed to the reactive aldehydes acrolein and malondialdehyde (MDA). These lesions are believed to form the basis for the observed c...

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Main Authors: Singh, Vipender, Fedeles, Bogdan I., Li, Deyu, Delaney, James C., Kozekov, Ivan D., Kozekova, Albena, Marnett, Lawrence J., Rizzo, Carmelo J., Essigmann, John M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164229/
https://ncbi.nlm.nih.gov/pubmed/25157679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5002817
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