Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody–drug conjugates (ADCs), in the clinic has had a major impact on the treatment of lymphoma and breast cancer patients, respectively, worldwide. Despite these successes many new ADCs fail at various stages of development, often d...

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Autors principals: Schumacher, Felix F., Nunes, João P. M., Maruani, Antoine, Chudasama, Vijay, Smith, Mark E. B., Chester, Kerry A., Baker, James R., Caddick, Stephen
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2014
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4159697/
https://ncbi.nlm.nih.gov/pubmed/25103319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob01550a
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