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Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging
The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody–drug conjugates (ADCs), in the clinic has had a major impact on the treatment of lymphoma and breast cancer patients, respectively, worldwide. Despite these successes many new ADCs fail at various stages of development, often d...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Royal Society of Chemistry
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4159697/ https://ncbi.nlm.nih.gov/pubmed/25103319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4ob01550a |
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