Extended N(6) Substitution of Rigid C2-Arylethynyl Nucleosides for Exploring the Role of Extracellular Loops in Ligand Recognition at the A(3) Adenosine Receptor

2-Arylethynyl-(N)-methanocarba adenosine 5′-methyluronamides containing rigid N(6)-(trans-2-phenylcyclopropyl) and 2-phenylethynyl groups were synthesized as agonists for probing structural features of the A(3) adenosine receptor (AR). Radioligand binding confirmed A(3)AR selectivity and N(6)-1S,2R...

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Bibliographic Details
Main Authors: Tosh, Dilip K., Paoletta, Silvia, Chen, Zhoumou, Moss, Steven M., Gao, Zhan-Guo, Salvemini, Daniela, Jacobson, Kenneth A.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4158450/
https://ncbi.nlm.nih.gov/pubmed/24969016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.06.006
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