Collaboration of Brca1 and Chk2 in tumorigenesis

Disruption of Brca1 results in cellular demise or tumorigenesis depending on cellular context. Inactivation of p53 contributes to Brca1-associated tumor susceptibility. However the activation of p53-dependent checkpoint/apoptotic signaling in the absence of Brca1 is poorly understood. Here, we show...

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Autori principali: McPherson, John Peter, Lemmers, Bénédicte, Hirao, Atsushi, Hakem, Anne, Abraham, Jacinth, Migon, Eva, Matysiak-Zablocki, Elzbieta, Tamblyn, Laura, Sanchez-Sweatman, Otto, Khokha, Rama, Squire, Jeremy, Hande, M. Prakash, Mak, Tak W., Hakem, Razqallah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC415639/
https://ncbi.nlm.nih.gov/pubmed/15131084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1192704
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