Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

The Drosophila melanogaster warts/lats tumour suppressor has two mammalian counterparts LATS1/Warts-1 and LATS2/Kpm. Here, we show that mammalian Lats orthologues exhibit distinct expression profiles according to germ cell layer origin. Lats2(−/−) embryos show overgrowth in restricted tissues of mes...

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Detalhes bibliográficos
Main Authors: McPherson, John Peter, Tamblyn, Laura, Elia, Andrew, Migon, Eva, Shehabeldin, Amro, Matysiak-Zablocki, Elzbieta, Lemmers, Bénédicte, Salmena, Leonardo, Hakem, Anne, Fish, Jason, Kassam, Farah, Squire, Jeremy, Bruneau, Benoit G, Hande, M Prakash, Hakem, Razqallah
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517611/
https://ncbi.nlm.nih.gov/pubmed/15343267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600371
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