Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

Defects in death receptor-mediated apoptosis have been linked to cancer and autoimmune disease in humans. The in vivo role of caspase 8, a component of this pathway, has eluded analysis in postnatal tissues because of the lack of an appropriate animal model. Targeted disruption of caspase 8 is letha...

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Main Authors: Salmena, Leonardo, Lemmers, Benedicte, Hakem, Anne, Matysiak-Zablocki, Elzbieta, Murakami, Kiichi, Au, P.Y. Billie, Berry, Donna M., Tamblyn, Laura, Shehabeldin, Amro, Migon, Eva, Wakeham, Andrew, Bouchard, Denis, Yeh, Wen Chen, McGlade, Jane C., Ohashi, Pamela S., Hakem, Razqallah
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196031/
https://ncbi.nlm.nih.gov/pubmed/12654726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1063703
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