RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis

The Rho proteins are Ras-related guanosine triphosphatases (GTPases) that function in cytoskeletal reorganization, cell migration, and stress fiber and focal adhesion formation. Overexpression of RhoC enhances the ability of melanoma cells to exit the blood and colonize the lungs. However, in vivo c...

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Bibliographic Details
Main Authors: Hakem, Anne, Sanchez-Sweatman, Otto, You-Ten, Annick, Duncan, Gordon, Wakeham, Andrew, Khokha, Rama, Mak, Tak W.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1199568/
https://ncbi.nlm.nih.gov/pubmed/16107613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1310805
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