Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer

Chk2 is an effector kinase important for the activation of cell cycle checkpoints, p53, and apoptosis in response to DNA damage. Mus81 is required for the restart of stalled replication forks and for genomic integrity. Mus81(Δex3-4/Δex3-4) mice have increased cancer susceptibility that is exacerbate...

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Bibliografski detalji
Glavni autori: El Ghamrasni, Samah, Pamidi, Ashwin, Halaby, Marie Jo, Bohgaki, Miyuki, Cardoso, Renato, Li, Li, Venkatesan, Shriram, Sethu, Swaminathan, Hirao, Atsushi, Mak, Tak W., Hande, Manoor Prakash, Hakem, Anne, Hakem, Razqallah
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098187/
https://ncbi.nlm.nih.gov/pubmed/21625617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001385
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