Cross-talk between Chk1 and Chk2 in double-mutant thymocytes

Chk1 is a checkpoint kinase and an important regulator of mammalian cell division. Because null mutation of Chk1 in mice is embryonic lethal, we used the Cre-loxP system and the Lck promoter to generate conditional mutant mice in which Chk1 was deleted only in the T lineage. In the absence of Chk1,...

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Detalhes bibliográficos
Main Authors: Zaugg, Kathrin, Su, Yu-Wen, Reilly, Patrick T., Moolani, Yasmin, Cheung, Carol C., Hakem, Razquallah, Hirao, Atsushi, Liu, Quinghua, Elledge, Stephen J., Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820665/
https://ncbi.nlm.nih.gov/pubmed/17360434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611584104
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