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Cross-talk between Chk1 and Chk2 in double-mutant thymocytes
Chk1 is a checkpoint kinase and an important regulator of mammalian cell division. Because null mutation of Chk1 in mice is embryonic lethal, we used the Cre-loxP system and the Lck promoter to generate conditional mutant mice in which Chk1 was deleted only in the T lineage. In the absence of Chk1,...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1820665/ https://ncbi.nlm.nih.gov/pubmed/17360434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0611584104 |
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