Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

[Image: see text] Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positive) topoisomerase IV through a cr...

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מידע ביבליוגרפי
Main Authors: Aldred, Katie J., Breland, Erin J., Vlčková, Vladislava, Strub, Marie-Paule, Neuman, Keir C., Kerns, Robert J., Osheroff, Neil
פורמט: Artigo
שפה:Inglês
יצא לאור: American Chemical Society 2014
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151693/
https://ncbi.nlm.nih.gov/pubmed/25115926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500682e
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