Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

[Image: see text] Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positive) topoisomerase IV through a cr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Aldred, Katie J., Breland, Erin J., Vlčková, Vladislava, Strub, Marie-Paule, Neuman, Keir C., Kerns, Robert J., Osheroff, Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151693/
https://ncbi.nlm.nih.gov/pubmed/25115926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500682e
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge