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Bacillus anthracis GrlA(V96A) Topoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge
The rise in quinolone resistance is threatening the clinical use of this important class of broad-spectrum antibacterials. Quinolones kill bacteria by increasing the level of DNA strand breaks generated by the type II topoisomerases gyrase and topoisomerase IV. Most commonly, resistance is caused by...
Enregistré dans:
| Publié dans: | Antimicrob Agents Chemother |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4249509/ https://ncbi.nlm.nih.gov/pubmed/25246407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03734-14 |
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