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Bacillus anthracis GrlA(V96A) Topoisomerase IV, a Quinolone Resistance Mutation That Does Not Affect the Water-Metal Ion Bridge

The rise in quinolone resistance is threatening the clinical use of this important class of broad-spectrum antibacterials. Quinolones kill bacteria by increasing the level of DNA strand breaks generated by the type II topoisomerases gyrase and topoisomerase IV. Most commonly, resistance is caused by...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Aldred, Katie J., Breland, Erin J., McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4249509/
https://ncbi.nlm.nih.gov/pubmed/25246407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03734-14
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