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Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance

[Image: see text] Gyrase appears to be the primary cellular target for quinolone antibacterials in multiple pathogenic bacteria, including Bacillus anthracis, the causative agent of anthrax. Given the significance of this type II topoisomerase as a drug target, it is critical to understand how quino...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biochemistry
Hauptverfasser: Ashley, Rachel E., Lindsey, R. Hunter, McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5560241/
https://ncbi.nlm.nih.gov/pubmed/28708938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00203
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