Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

[Image: see text] Although quinolones have been in clinical use for decades, the mechanism underlying drug activity and resistance has remained elusive. However, recent studies indicate that clinically relevant quinolones interact with Bacillus anthracis (Gram-positive) topoisomerase IV through a cr...

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Hlavní autoři: Aldred, Katie J., Breland, Erin J., Vlčková, Vladislava, Strub, Marie-Paule, Neuman, Keir C., Kerns, Robert J., Osheroff, Neil
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151693/
https://ncbi.nlm.nih.gov/pubmed/25115926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500682e
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