4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a nucleoside analog that, unlike approved anti-human immunodeficiency virus type 1 (HIV-1) nucleoside reverse transcriptase inhibitors, has a 3′-OH and exhibits remarkable potency against wild-type and drug-resistant HIVs. EFdA triphosphate (EFdA-TP) i...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Michailidis, Eleftherios, Huber, Andrew D., Ryan, Emily M., Ong, Yee T., Leslie, Maxwell D., Matzek, Kayla B., Singh, Kamalendra, Marchand, Bruno, Hagedorn, Ariel N., Kirby, Karen A., Rohan, Lisa C., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Microbiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148878/
https://ncbi.nlm.nih.gov/pubmed/24970894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562694
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker