4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a nucleoside analog that, unlike approved anti-human immunodeficiency virus type 1 (HIV-1) nucleoside reverse transcriptase inhibitors, has a 3′-OH and exhibits remarkable potency against wild-type and drug-resistant HIVs. EFdA triphosphate (EFdA-TP) i...

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Detalhes bibliográficos
Main Authors: Michailidis, Eleftherios, Huber, Andrew D., Ryan, Emily M., Ong, Yee T., Leslie, Maxwell D., Matzek, Kayla B., Singh, Kamalendra, Marchand, Bruno, Hagedorn, Ariel N., Kirby, Karen A., Rohan, Lisa C., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148878/
https://ncbi.nlm.nih.gov/pubmed/24970894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562694
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