Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) form the backbone of most anti-HIV therapies. We have shown that 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly effective NRTI; however, the reasons for the potent antiviral activity of EFdA are not well understood. Here, we use a comb...

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Détails bibliographiques
Auteurs principaux: Kirby, Karen A., Michailidis, Eleftherios, Fetterly, Tracy L., Steinbach, Musetta A., Singh, Kamalendra, Marchand, Bruno, Leslie, Maxwell D., Hagedorn, Ariel N., Kodama, Eiichi N., Marquez, Victor E., Hughes, Stephen H., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2013
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837839/
https://ncbi.nlm.nih.gov/pubmed/24100493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-13
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