Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) form the backbone of most anti-HIV therapies. We have shown that 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly effective NRTI; however, the reasons for the potent antiviral activity of EFdA are not well understood. Here, we use a comb...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Kirby, Karen A., Michailidis, Eleftherios, Fetterly, Tracy L., Steinbach, Musetta A., Singh, Kamalendra, Marchand, Bruno, Leslie, Maxwell D., Hagedorn, Ariel N., Kodama, Eiichi N., Marquez, Victor E., Hughes, Stephen H., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837839/
https://ncbi.nlm.nih.gov/pubmed/24100493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-13
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller