Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) form the backbone of most anti-HIV therapies. We have shown that 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly effective NRTI; however, the reasons for the potent antiviral activity of EFdA are not well understood. Here, we use a comb...

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Autori principali: Kirby, Karen A., Michailidis, Eleftherios, Fetterly, Tracy L., Steinbach, Musetta A., Singh, Kamalendra, Marchand, Bruno, Leslie, Maxwell D., Hagedorn, Ariel N., Kodama, Eiichi N., Marquez, Victor E., Hughes, Stephen H., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837839/
https://ncbi.nlm.nih.gov/pubmed/24100493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-13
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