Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) form the backbone of most anti-HIV therapies. We have shown that 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly effective NRTI; however, the reasons for the potent antiviral activity of EFdA are not well understood. Here, we use a comb...

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Xehetasun bibliografikoak
Egile Nagusiak: Kirby, Karen A., Michailidis, Eleftherios, Fetterly, Tracy L., Steinbach, Musetta A., Singh, Kamalendra, Marchand, Bruno, Leslie, Maxwell D., Hagedorn, Ariel N., Kodama, Eiichi N., Marquez, Victor E., Hughes, Stephen H., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2013
Gaiak:
Antiviral Agents
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837839/
https://ncbi.nlm.nih.gov/pubmed/24100493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-13
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