Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is the most potent nucleoside analog inhibitor of HIV reverse transcriptase (RT). It retains a 3′-OH yet acts as a chain-terminating agent by diminishing translocation from the pretranslocation nucleotide-binding site (N site) to the posttranslocation pri...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Salie, Zhe Li, Kirby, Karen A., Michailidis, Eleftherios, Marchand, Bruno, Singh, Kamalendra, Rohan, Lisa C., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995989/
https://ncbi.nlm.nih.gov/pubmed/27489345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605223113
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