Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

BACKGROUND: The K65R substitution in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is the major resistance mutation selected in patients treated with first-line antiretroviral tenofovir disoproxil fumarate (TDF). 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), is the...

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Hlavní autoři: Michailidis, Eleftherios, Ryan, Emily M, Hachiya, Atsuko, Kirby, Karen A, Marchand, Bruno, Leslie, Maxwell D, Huber, Andrew D, Ong, Yee T, Jackson, Jacob C, Singh, Kamalendra, Kodama, Eiichi N, Mitsuya, Hiroaki, Parniak, Michael A, Sarafianos, Stefan G
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695782/
https://ncbi.nlm.nih.gov/pubmed/23800377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-65
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