K70Q Adds High-Level Tenofovir Resistance to “Q151M Complex” HIV Reverse Transcriptase through the Enhanced Discrimination Mechanism

HIV-1 carrying the “Q151M complex” reverse transcriptase (RT) mutations (A62V/V75I/F77L/F116Y/Q151M, or Q151Mc) is resistant to many FDA-approved nucleoside RT inhibitors (NRTIs), but has been considered susceptible to tenofovir disoproxil fumarate (TFV-DF or TDF). We have isolated from a TFV-DF-tre...

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Autores principales: Hachiya, Atsuko, Kodama, Eiichi N., Schuckmann, Matthew M., Kirby, Karen A., Michailidis, Eleftherios, Sakagami, Yasuko, Oka, Shinichi, Singh, Kamalendra, Sarafianos, Stefan G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020970/
https://ncbi.nlm.nih.gov/pubmed/21249155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016242
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