Clinical relevance of substitutions in the connection subdomain and RNase H domains of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients

Some mutations in the connection subdomain of the polymerase domain and in the RNase H domain of HIV-1 reverse transcriptase (RT) have been shown to contribute to resistance to RT inhibitors. However, the clinical relevance of such mutations is not well understood. To address this point we determine...

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Hauptverfasser: Hachiya, Atsuko, Shimane, Kazuki, Sarafianos, Stefan G., Kodama, Eiichi N., Sakagami, Yasuko, Negishi, Fujie, Koizumi, Hirokazu, Gatanaga, Hiroyuki, Matsuoka, Masao, Takiguchi, Masafumi, Oka, Shinichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481171/
https://ncbi.nlm.nih.gov/pubmed/19428602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2009.02.189
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