Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

We identified clinical isolates with phenotypic resistance to nevirapine (NVP) in the absence of known nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations. This resistance is caused by N348I, a mutation at the connection subdomain of human immunodeficiency virus type 1 (HIV-1) reverse tr...

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Detalhes bibliográficos
Main Authors: Hachiya, Atsuko, Kodama, Eiichi N., Sarafianos, Stefan G., Schuckmann, Matthew M., Sakagami, Yasuko, Matsuoka, Masao, Takiguchi, Masafumi, Gatanaga, Hiroyuki, Oka, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268505/
https://ncbi.nlm.nih.gov/pubmed/18216099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01154-07
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