EFFECT OF TRANSLOCATION DEFECTIVE REVERSE TRANSCRIPTASE INHIBITORS ON THE ACTIVITY OF N348I, A CONNECTION SUBDOMAIN DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE MUTANT

4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly potent inhibitor of HIV-1 reverse transcriptase (RT). We have previously shown that its exceptional antiviral activity stems from a unique mechanism of action that is based primarily on blocking translocation of RT; therefore we named EFdA a T...

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Detalhes bibliográficos
Main Authors: MICHAILIDIS, E., SINGH, K., RYAN, E.M., HACHIYA, A., ONG, Y.T., KIRBY, K.A., MARCHAND, B., KODAMA, E.N., MITSUYA, H., PARNIAK, M.A., SARAFIANOS, S.G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551986/
https://ncbi.nlm.nih.gov/pubmed/23273211
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