Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor

Nucleoside reverse transcriptase inhibitors (NRTIs) are employed in first line therapies for the treatment of human immunodeficiency virus (HIV) infection. They generally lack a 3′-hydroxyl group, and thus when incorporated into the nascent DNA they prevent further elongation. In this report we show...

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Bibliografiske detaljer
Main Authors: Michailidis, Eleftherios, Marchand, Bruno, Kodama, Eiichi N., Singh, Kamlendra, Matsuoka, Masao, Kirby, Karen A., Ryan, Emily M., Sawani, Ali M., Nagy, Eva, Ashida, Noriyuki, Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790999/
https://ncbi.nlm.nih.gov/pubmed/19837673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036616
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